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Relational problems (those with many possible valid outputs) are different from decision problems, but it is easy to forget just how different. This paper initiates the study of FBQP/qpoly, the class of relational problems solvable in quantum polynomial-time with the help of polynomial-sized quantum advice, along with its analogues for deterministic and randomized computation (FP, FBPP) and advice (/poly, /rpoly). Our first result is that FBQP/qpoly ≠ FBQP/poly, unconditionally, with no oracle - a striking contrast with what we know about the analogous decision classes. The proof repurposes the separation between quantum and classical one-way communication complexities due to Bar-Yossef, Jayram, and Kerenidis. We discuss how this separation raises the prospect of near-term experiments to demonstrate "quantum information supremacy," a form of quantum supremacy that would not depend on unproved complexity assumptions. Our second result is that FBPP ̸ ⊂ FP/poly - that is, Adleman’s Theorem fails for relational problems - unless PSPACE ⊂ NP/poly. Our proof uses IP = PSPACE and time-bounded Kolmogorov complexity. On the other hand, we show that proving FBPP ̸ ⊂ FP/poly will be hard, as it implies a superpolynomial circuit lower bound for PromiseBPEXP. We prove the following further results: - Unconditionally, FP ≠ FBPP and FP/poly ≠ FBPP/poly (even when these classes are carefully defined). - FBPP/poly = FBPP/rpoly (and likewise for FBQP). For sampling problems, by contrast, SampBPP/poly ≠ SampBPP/rpoly (and likewise for SampBQP).